吴迪

教学育人成果：

（1）浙江省青年教师教学比赛理科组——特等奖

（2）温州医科大学青年教师教学比赛——特等奖、温州医科大学教学创新大赛——特等奖

（3）温州医科大学“教坛新秀”

（4）全国生命科学竞赛（创新创业类），国家级二等奖，指导教师。

科研成果：

1.科研项目

（1）国家自然科学基金青年项目，81803345，基于蛋白相互作用的CD14多肽类抑制剂的设计及其对脓毒血症的药理作用研究，21万，主持

（2）浙江省自然科学基金探索项目Y，LY20H31006，定向优化的抗菌肽MS-PT1抗脓毒血症药理及机制研究，9万，主持

（3）国家自然科学基金国际合作项目，20191142009，天然产物靶向MD2炎症反应防治代谢性心脏病的新药发现研究，200万，参与（2/8）

2.发表论文（具有代表性的5篇）

（1）Yang, J., Tong, C., Qi, J., Liao, X., Li, X., Zhang, X., Zhou, M., Wang, L., Ma, C., Xi, X., Chen, T., Gao, Y., Wu, D., 2022. Engineering and Structural Insights of a Novel BBI-like Protease Inhibitor Livisin from the Frog Skin Secretion. Toxins 14, 273.

（2）Zhang, J., Chen, P., Duan, Y., Xiong, H., Li, H., Zeng, Y., Liang, G., Tang, Q., Wu, D., 2021. Design, synthesis and biological evaluation of 7H-pyrrolo[2,3-d]pyrimidinederivatives containing 1,8-naphthyridine-4-one fragment. Eur. J. Med. Chem. 215, 113273.

（3）Song, X., Pan, H., Wang, H., Liao, X., Sun, D., Xu, K., Chen, T., Zhang, X., Wu, M., Wu, D., Gao, Y., 2020. Identification of new dermaseptins with self-assembly tendency: membrane disruption, biofilm eradication, and infected wound healing efficacy. Acta Biomater. 109, 208–219.

（4）Wu, D., Gao, Y., Tan, Y., Liu, Y., Wang, L., Zhou, M., Xi, X., Ma, C., Bininda-Emonds, O.R.P., Chen, T., Shaw, C., 2018. Discovery of Distinctin-Like-Peptide-PH (DLP-PH) From the Skin Secretion of Phyllomedusa hypochondrialis, a Prototype of a Novel Family of Antimicrobial Peptide. Front. Microbiol. 9, 541.

（5）Gao, Y., Wu, D., Wang, L., Lin, C., Ma, C., Xi, X., Zhou, M., Duan, J., Bininda-Emonds, O.R.P., Chen, T., Shaw, C., 2017. Targeted Modification of a Novel Amphibian Antimicrobial Peptide from Phyllomedusa tarsius to Enhance Its Activity against MRSA andMicrobial Biofilm. Front. Microbiol. 8.